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SGLT-2 vs. GLP-1: Cardiovascular Outcomes in Adults with Type 2 Diabetes

Oct 3, 2020
Editor: David L. Joffe, BSPharm, CDE, FACA

Author: Tarshay Boyd, PharmD. Candidate, LECOM School of Pharmacy

Cardiovascular events decline for patients using which antidiabetic medication?

Life threatening cardiovascular events can take place with uncontrolled type 2 diabetes, including death, heart failure, stroke, and myocardial infarction. Patients can also suffer from acute kidney disease. The purpose of this study is to compare the use of two antidiabetic medications, SGLT-2 inhibitor and GLP-1 receptor agonist, as it pertains to cardiovascular events.  Previous studies, Dapagliflozin Effect on Cardiovascular Events (DECLARE) and Researching Cardiovascular Events with a Weekly Incretin in Diabetes (REWIND) documented cardiovascular benefits for both medications.  Another analysis performed on Italian outpatients with diabetes found benefits in glycemic control, HbA1c, blood pressure, and body weights were comparable. The authors stated that no clinical trials determine which drug is more effective in type 2 patients to protect them from cardiovascular events....


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