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Pre-Diabetes Increases Risk of CVD and All-Cause Mortality

Aug 1, 2020
Editor: David L. Joffe, BSPharm, CDE, FACA

Author: Fairuz Afram, PharmD Candidate, University of Colorado, Skaggs School of Pharmacy and Pharmaceutical Sciences

Numerous complications associated with diabetes, including CVD (cardiovascular disease) and the risk of death, begin with pre-diabetes.

The American Diabetes Association defines pre-diabetes as a borderline glycemia measured by fasting plasma glucose (FPG) of 100-125 mg/dL, 2-h plasma glucose (2hPG) of 140–199 mg/dL, and HbA1c of 5.7–6.4%.


People with pre-diabetes have shown early stages of retinopathy, nephropathy, and neuropathy. Other disorders typically associated with diabetes have been observed in people with pre-diabetes, such as cardiovascular disease, periodontal disease, cognitive dysfunction, obstructive sleep apnea, metabolic syndrome, fatty liver, and cancer....

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