May 6, 2017 : Issue #884

• AACE: Fourth Complication From Type 2 Diabetes: Heart Failure
• Importance of GI Events for GLP-1 Receptor Agonists
• Greater Risk For Stroke and Dementia from Artificially Sweetened Beverages
• Type 1 Cured in Mice
• Diabetes Risk Reduction Seen with a Digital Health Program, Human Coaching
• Resistance Training for Older Adults and Anyone with Reduced Mobility
  • By Sheri Colberg, Ph.D.

Diabetes research can be a very fickle world at times. Over the years we have heard of many “cures” for type 1 diabetes. Most of the time the discoverer is someone not well known in the diabetes community and the work is dismissed as pie in the sky. This kind of judgement may also affect how and when some of our most well respected researchers will participate in endorsing new ideas. This week we are fortunate to have information on a possible new cure for humans that has worked well in mice.

What makes this all the more impressive is that the researcher is without a doubt one of the most respected in the world.

To find out who he is and what his solution is, be sure to read article #4.

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We can make a difference!

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Dave Joffe

Editor-in-chief

Xultophy 100/3.6 (insulin degludec and liraglutide) injection is now available as an adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes inadequately controlled on basal insulin (<50 units daily) or liraglutide (≤1.8mg daily).

Should prediabetes be considered a pre-existing condition? Follow the link to share your opinion!

Sanofi’s My Dose Coach app joins other insulin dosing apps recently cleared by the FDA, and new dosing tools from Novo Nordisk/Glooko. Sanofi’s My Dose Coach, a new, under-the-radar mobile app for adjusting basal insulin doses for those on injections, received FDA clearance in late March. A healthcare provider prescribes and sets up the My Dose Coach mobile app so that it can suggest optimized basal insulin injection doses for people with diabetes. The app will use fasting blood glucose and hypoglycemia data and recommend changes in doses if readings are too high or too low. Release date is unknown.

A 62-year-old man presents with type 2 diabetes, hypertension, and albuminuria. His seated BP is 162/104 mm Hg. What’s an ideal blood pressure target for this patient?

A. 140/90 mm Hg
B. 130/80 mm Hg
C. 120/70 mm Hg
D. 150/80 mm HG

Did you get it right? Follow the link to find out!

A new study shows that cinnamon is involved in insulin regulation and can lower blood sugars. This study helps to show that people with type 2 diabetes who took cinnamon supplements had greater reductions in blood glucose levels than those who took a placebo. Scientists have long suspected that cinnamon can help prevent blood sugar spikes and protect against insulin resistance, but how, exactly, has remained a mystery. And while some studies have suggested a strong effect, others have been inconclusive.  The objective of this study was to determine whether cinnamon improves blood glucose, triglyceride, total cholesterol, HDL cholesterol, and LDL cholesterol levels in people with type 2 diabetes. A total of 60 people with type 2 diabetes, 30 men and 30 women age 52.2 ± 6.32 years, were divided randomly into six groups. Groups 1, 2, and 3 consumed 1, 3, or 6 g of cinnamon daily, respectively, and groups 4, 5, and 6 were given placebo capsules. The cinnamon was consumed for 40 days followed by a 20-day washout period.  The results of this study demonstrate that intake of 1, 3, or 6 g of cinnamon per day reduces serum glucose, triglyceride, LDL cholesterol, and total cholesterol in people with type 2 diabetes, and suggest that the inclusion of cinnamon in the diet of people with type 2 diabetes will reduce risk factors associated with diabetes and cardiovascular diseases. The incidence of cardiovascular diseases is increased two- to fourfold in people with type 2 diabetes. It has been postulated that spices may play a role. Spices such as cinnamon, cloves, bay leaves, and turmeric display insulin-enhancing activity in vitro. Botanical products can improve glucose metabolism and the overall condition of individuals with diabetes not only by hypoglycemic effects but also by improving lipid metabolism, antioxidant status, and capillary function. A number of medicinal/culinary herbs have been reported to yield hypoglycemic effects in patients with diabetes. Examples of these include bitter melon, Gymnema, Korean ginseng, onions, garlic, flaxseed meal, and specific nutrients including α-lipoic acid, biotin, carnitine, vanadium, chromium, magnesium, zinc, and vitamins B3, E, and K. — J Acad Nutr Diet. 2016 Nov;116(11):1794-1802. doi: 10.1016/j.jand.2016.07.015. Epub 2016 Sep 8.

More rigorous screening called for to mitigate poor outcomes of this common condition.

Study finds fewer T2 patients on exenatide once-weekly reported gastrointestinal adverse events, compared with those on exenatide twice-daily or liraglutide once-daily.

Framingham Heart Study Offspring cohort does not find similar association for sugar-sweetened drinks.

Ralph DeFronzo and his researchers at UT Health at San Antonio announced that they have cured type 1 diabetes.

Study measures effects of apps on weight reduction.

In addition to aerobic activities, you can greatly improve your blood glucose by doing some resistance, or weight, training. Like so many systems in the body, if you don’t use all your muscle fibers, you lose them over time.

Quote of the Week!

“You cannot control what happens to you, but you can control your attitude toward what happens to you, and in that, you will be mastering change rather than allowing it to master you.”

…Brian Tracy

Diabetes in Control gratefully acknowledges the assistance of the following pharmacy doctoral candidates in the preparation of this week’s newsletter:

Mark T. Lawrence, University of Colorado-Denver, School of Pharmacy NTPD

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