June 13, 2020 : Issue #1046

TOP STORIES — Diabetes News and Research

A Link Between ESRD and Low BMI

Breastfeeding Key To Preventing T2DM

Could a Diabetes Medication Affect COVID-19 Outcomes?

As the US continues to relax stay at home policies and social distancing, there has been an increase in diagnosed Covid-19 cases. Here in Florida the past two days have seen the highest counts of new positives since we started collecting data back in March. And it looks like it is bound to get worse before it gets better.

I am not saying that wearing a mask guarantees you won’t get Covid-19, but when you walk into a store and only 5% of the patrons have a mask on, you have to think the worst.

There are a lot of companies looking for a cure and last Saturday our good friend, Joe Graedon, from the People’s Pharmacy, had an epidemiologist speaking about the rush to find current medications that may be able to be re-purposed to help Covid patients.

Interestingly enough, our current intern, Jacob Roberts, PharmD Candidate 2021 of University of Colorado Denver Skaggs School of Pharmacy and Pharmaceutical Sciences, was looking for diabetes medications that may be re-purposed and found that DPP4-Inhibitors may hold promise in the near future. Check out the article here.

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We can make a difference!

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Dave Joffe

Editor-in-chief

Study of BMI and ESRD suggests obesity may provide a health benefit when it comes to end-stage renal disease.

Prolonged lactation may reduce the risk for women with a history of gestational diabetes. 

Research into the interaction of DPP4 and coronavirus may be a step toward a cure. 

Consuming high-quality carbohydrates, particularly whole grains, lowered the risk for type 2 diabetes, according to data presented at Nutrition 2020 Live Online, June 1-4, 2020. The results were from analysis of dietary data for three large prospective U.S. cohorts, encompassing more than 200,727 participants who were enrolled in the Nurses’ Health Study, Nurses’ Health Study II, and Health Professionals Follow-up Study. Collectively, their analysis represented almost 4 million years of follow-up. The researchers identified 11,872 documented cases of type 2 diabetes in their analysis. They found that replacing 5% of energy from saturated fat with 5% of energy from low-quality carbohydrates — refined grains, sugary foods, and potatoes — was associated with a higher type 2 diabetes risk (HR = 1.05; 95% CI, 1-1.09). However, substituting 5% of energy from saturated fat with high- quality carbohydrates, such as whole-grain bread, brown rice, rye, barley, and quinoa, was associated with a lower type 2 diabetes risk (HR = 0.93; 95% CI, 0.87-0.99).  

Further, the isocaloric substitution of other macronutrients with low-quality carbohydrates was not associated with type 2 diabetes risk. Conversely, isocaloric substitution of high-quality carbohydrates was associated with lower type 2 diabetes risk when the replacement nutrient was monounsaturated fat (HR = 0.88; 95% CI, 0.83-0.94), animal protein (HR = 0.88; 95% CI, 0.83-0.93), vegetable protein (HR = 0.9; 95% CI, 0.84-0.96), trans fat (HR = 0.9; 95% CI, 0.85-0.97) and polyunsaturated fat (HR = 0.92; 95% CI, 0.86-0.98. 

“When individuals consume a low-fat diet, the replacement nutrient is almost always low quality or refined carbohydrates that this study shows to be associated with a higher risk for type 2 diabetes,” noted the researchers; “The quality of carbohydrate matters.” 

Journal of Nutrition 2020      Diabetologia 2020

Diabetes in Control gratefully acknowledges the assistance of the following pharmacy doctoral candidates in the preparation of this week’s newsletters:

Stephanie Anderson, PharmD Candidate 2021, Skaggs School of Pharmacy and Pharmaceutical Sciences

Antonio Bess, Pharm D Candidate, Florida Agricultural & Mechanical University School of Pharmacy

George McConnell, PharmD. Candidate, LECOM School of Pharmacy

Jacob Roberts, PharmD Candidate 2021 of University of Colorado Denver Skaggs School of Pharmacy and Pharmaceutical Sciences 

Chardae Whitner PharmD Candidate L|E|C|O|M Bradenton School of Pharmacy

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Steve and Dave
Diabetes In Control
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