Diabetes In Control. A free weekly diabetes newsletter for Medical Professionals. News and information for Medical Professionals.
Letter from the Editor
I am at the NCPA meeting in San Diego this weekend, and while I was on the plane I was rereading The 4-Hour Body, by Tim Ferriss. In one section of the book he talks about the slow carb diet and delves into how reducing carbs can actually reverse hypertension and lower cholesterol. This week our intern, Marian Ayad, BSPharm, BCPS, PharmD candidate, University of Colorado, brings us the results of a large study that shows how this slow carb method can actually reverse metabolic syndrome, and prevent diabetes.
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We can make a difference!
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Dave Joffe
Editor-in-chief
TOP STORIES -- Diabetes News and Research
Unique directions for taking the pill may cause a compliance issue; it’s not as simple as just taking a pill once a day.
Data from Randomized Clinical Trial on treating corticosteroid-induced hyperglycemia with the use of NPH insulin protocol therapy.
This study discusses how restricting carbohydrates can reverse and prevent the metabolic syndrome.
Fact: HbA1c or OGTT to Diagnose?
The oral glucose tolerance test has been the gold standard in diagnosing diabetes and prediabetes. Glycated Hemoglobin (HbA1c) has been used for some years to diagnose prediabetes and diabetes also, but is currently under extensive discussion for contradictory data on the concordance between this test and the oral glucose tolerance test (OGTT). In order to assess the concordance between HbA1c and OGTT to diagnose prediabetes and diabetes in patients who have overweight or obesity the following study was done. A total of 949 outpatients with overweight or obesity at risk for diabetes (mean age 50 ± 15 years; 660 F) were enrolled and underwent HbA1c test and OGTT. From the results, they found that in both genders, HbA1c test identified more patients with prediabetes than OGTT (42% vs 22% in males, 40% vs 18% in females, respectively); a slight concordance between HbA1c and OGTT (60% of total tests in both genders). In subjects diagnosed by OGTT, post‐OGTT insulin levels and HOMA INDEX were significantly higher than those found in HbA1c(+) cases. Instead, those diagnosed with HbA1c were significantly older and showed higher uric acid than those with both tests (−). The results showed that the HbA1c test and OGTT did not reach full concordance for the diagnosis of diabetes and prediabetes in both genders. The two tests likely reflect different physiopathological aspects of dysglycemia, suggesting that the “diagnostic thresholds” could be reconsidered in light of the discordance observed. Clin Endocrinol. 2019;91(3):411-416.
Diabetes in Control gratefully acknowledges the assistance of the following pharmacy doctoral candidates in the preparation of this week’s newsletters:
Marian Ayad, BPharm, PharmD candidate, University of Colorado Skaggs School of Pharmacy and Pharmaceutical Sciences
Nadeen Ayad, BCPS, PharmD Candidate, Skaggs School of Pharmacy, University of Colorado
Hira Gohar, Florida A&M University, College of Pharmacy, PharmD Candidate
Alessa Grieff, PharmD candidate, University of South Florida College of Pharmacy
Nour Salhab, Pharm.D. Candidate, USF College of Pharmacy
Taylor-Eugene Simmons, Florida A&M University, College of Pharmacy & Pharmaceutical Sciences, PharmD Candidate
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