Diabetes In Control. A free weekly diabetes newsletter for Medical Professionals. News and information for Medical Professionals.
NEWS FLASH: Hormone Levels May Predict PCOS in Premenarchal Girls
DISASTERS AVERTED — Near Miss Case Studies
Be Aware, Proactive to Manage PCOS
TOP STORIES — Diabetes News and Research
- The Effect of Metformin On Patients Who Are Pregnant and Have PCOS
- Does Canagliflozin Increase Risk of Fracture In Patients With Diabetes?
- Diabetic Ketoacidosis And The Developing Brain
CLINICAL GEMS — The Best from Diabetes Texts
MOST POPULAR ARTICLES OF THE MONTH
#1 Aiming for an Ideal Exercise Blood Glucose
#2 Benefits of Non-Sugar Sweeteners and Health Outcomes: Conflicting
#3 Carbs Content Alone Not Enough for Insulin Calculations
Editor's Note
Whether you believe in global warming or not one thing is for sure: fungi, bacteria and viruses that were frozen in the Ice Age are starting to thaw out at both of the polar ice caps and previously tundra areas. The question is, are they still active, will they come back to life and spread diseases we no longer have immunity for? This week in our Clinical Text we look at how this same concept may explain how TIDM occurs. Be sure to read about “missing heritability.”
And while we are talking about heritability be sure to review how PCOS could be hereditarily related and how our own Medical Editor, Joy Pape, made sure that what was in the past helped a young lady take care of the present.
Dave Joffe
Editor-in-chief
DISASTERS AVERTED — Near Miss Case Studies
Woman, 43 years of age, PCOS, prediabetes, BMI 26, B/P 130/70, A1C 5.5%, Lipids, TC-156, HDL 52, Trig 76, LDL 84, mother of 3 children, visited today. She reports that her mother had PCOS, so was very carefully watching her as a child and adolescent hoping to prevent her from developing the complications of PCOS, such as infertility, obesity, type 2 diabetes, cardiovascular disease, and/or cancer later in life.
Research suggests testosterone and AMH levels could be used to predict risk for PCOS in premenarchal daughters of women with PCOS.
TOP STORIES — Diabetes News and Research
Treatment throughout pregnancy may reduce rate of miscarriage or preterm delivery.
CANVAS Program shows reduced heart events but increased risk of side effects.
Single episode of moderate/severe DKA in young children at diagnosis associated with lower cognitive scores, altered brain growth.
CLINICAL GEMS — The Best from Diabetes Texts
Other genetic markers—the “missing heritability”:
Collectively the confirmed T1DM risk loci account for approximately 70% of disease heritability, with around 40–50% being attributed to the HLA genes. These figures are well in excess of the 10–20% of heritability of other complex diseases that can be explained by genetic factors. Experience from GWAS suggests that overall disease risk is likely to be influenced by many genes, most having a weak biologic effect. This may be due to the subtle effects of risk alleles on gene function or the modest contribution of individual gene products to the biologic pathways involved in disease pathogenesis. None of the confirmed T1DM risk variants have complete penetrance and are therefore neither necessary nor sufficient for disease to develop. This makes it difficult to use genetic profiling to predict disease risk as T1DM can develop in the absence of susceptibility variants and does not always occur in subjects with known risk markers.