March 12, 2019 : DCMS #440

TOP STORIES — Diabetes News and Research

• Probiotics Effects On Insulin Resistance
• Gestational Diabetes Effects on Childhood Glucose Metabolism
• Metformin Safety In Patients With Chronic Kidney Disease And Its Benefits

EXCLUSIVE INTERVIEW — Candid Video Interviews with Top Practitioners

Jeffrey Emmick on Lilly Diabetes Products

CLINICAL GEMS — The Best from Diabetes Texts

International Textbook of Diabetes Mellitus, 4th Ed., Excerpt #168: Molecular Genetics of Type 1 Diabetes Part 5

MOST POPULAR ARTICLES OF THE MONTH

#1 Can Green Tea Increase The Risk For Type 2 Diabetes?
#2 Aiming for an Ideal Exercise Blood Glucose
#3 Benefits of Non-Sugar Sweeteners and Health Outcomes: Conflicting

Years ago, we only had a couple of drugs for diabetes and we wanted more. Then, in the past 10 years, we have had an explosion of drugs and you can bet there are more coming soon. This week, Joy Pape sits down with Jeffery Emmick from Eli Lilly to discuss what they have in the pipeline and what we have to look forward to.

Dave Joffe

Editor-in-chief

Probiotic supplements may be considered as an adjunct treatment for glycemic control in women who are pregnant and have gestational diabetes.

Children of mothers with untreated gestational diabetes mellitus are at risk of insulin resistance and impairment in glucose metabolism.

In patients with stage 3 kidney disease, metformin use may be safe and may reduce the risk of mortality and cardiovascular events.

Jeffrey Emmick MD, Ph.D is the vice president of product development at Eli Lilly and Company. Dr. Emmick has been with the organization for over 20 years in various roles. Currently, he is responsible for late-stage clinical development for the entire Lilly diabetes portfolio.

Linkage studies identify regions of the genome that are shared more frequently than would be expected by chance by relatives affected by a particular disease. Most studies analyze affected sibling pairs and utilize genetic markers that are scattered throughout the genome at moderate density, typically microsatellites. A significant excess of allele sharing identical by-descent (IBD) in affected sibpairs suggests that the region containing the marker locus also contains a disease susceptibility locus. The first linkage scan for T1DM identified 20 chromosomal regions with suggestive evidence of linkage to disease, including the HLA and INS gene regions.

People consistently drinking green tea may not be getting all the benefits as hoped.

By Sheri R. Colberg, PhD, FACSM

There is no official ideal blood glucose range to start with and maintain during physical activity, but we do know that being too low negatively impacts performance, as does being too high. As for what blood glucose target or range most athletes aim for, it depends on a number of factors, including the type, intensity, and duration of their activity. A consensus statement about exercise and type 1 diabetes published in The Lancet in 2017 suggested that a reasonable target for most people doing aerobic exercise lasting up to an hour is 126 to 180 mg/dL (7.0 to 10.0 mmol/L), only aiming higher for added protection against lows in some situations.

While increased cancer risk was not found, overall study of sweeteners vs sugar remains inconclusive.