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New Protein Found that Causes Inflammatory Response Leading to Insulin Resistance

Nov 12, 2010
 

New Protein Found that Causes Inflammatory Response Leading to Insulin Resistance: It has long been known that overactive immune cells can cause inflammation throughout the body, leading to insulin resistance and eventually Type 2 diabetes. Now, a new study has found a protein that plays a vital part of regulating this process. The findings indicate that the protein FoxO1 partially regulates the activity of macrophages, a type of white blood cell that responds to invasions from foreign bodies but can also become overactive, causing swelling. This is particularly harmful for people who already experience swelling, such as obese individuals. The added inflammation caused by overactive macrophages may contribute to insulin resistance and diabetes. FoxO1 primes macrophages to respond exuberantly to inflammation. The research results could lay the groundwork for future treatments that use the FoxO1 protein as a target to prevent the development of Type 2 diabetes. Journal of the European Molecular Biology Association, Nov 2010