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How a Certain Virus Can Cause Diabetes

Apr 6, 2021
Editor: David L. Joffe, BSPharm, CDE, FACA

Author: Arjay Mendoza, PharmD Candidate, University of Colorado Denver Skaggs School of Pharmacy and Pharmaceutical Sciences

A new study shows that a particular type of enterovirus can trigger a MODY4-like diabetes in affected patients. 

A research team from the Growth Factors, Nutrients, and Cancer Group, led by Dr. Nabil Djouder at the Spanish National Cancer Research Centre (CNIO), demonstrated how the enterovirus, Coxsackievirus B Type 4 (CVB4), could induce diabetes in affected patients. Their findings, which were published in the scientific journal Cell Reports Medicine, showed that the CBV4 infection in mice induced downregulation of URI, a protein that controls various cellular functions. This downregulation caused a cascade of molecular events, including the Pdx1 gene's silencing, which could eventually trigger diabetes in patients who have the enterovirus....


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