A couple of questions came up last week during a review of SGLT-2 inhibitors by my interns. The first question had to do with what was happening with SGLT-1 receptors in the research, as one of the students had remembered that there are 8 or more DPP receptors and wondered if there were other SGLT receptors. A quick literature search showed that SGLT-1 receptors are found in the small intestines and can have an effect on GLP-1 and GIP.
The second question had to do with the ability of the kidneys to effectively remove excess glucose when they had lost some of their function and would the SGLT-2 inhibitors work in those patients? To find out how effective the inhibitors are, check out this article on How SGLT-2 Inhibitors Work with Mild Renal Loss.