Type 2 Diabetes

Restoring Insulin Secretion (RISE) Pediatric Medication Study shows that youth have markedly reduced insulin sensitivity and respond differently to medications.

Analysis of European Steno 2 study examines long-term economic implications of interventions targeting complications.

The natural history of T2DM has been well described in multiple populations and is reviewed in references [1] and [3]. Individuals destined to develop T2DM inherit a set of genes from their parents that make their tissues resistant to insulin and the insulin resistance is aggravated by weight gain and physical inactivity. Hepatic insulin resistance is manifested by an overproduction of glucose during the basal state despite the presence of fasting hyperinsulinemia [38] and an impaired suppression of hepatic glucose production (HGP)

Study describes patient characteristics that place patients with type 2 diabetes at increased risk for severe hypoglycemia.

Discrepancies prompt additional analyses of ACCORD-BP and SPRINT studies to determine best blood pressure target for those with diabetes.

Use of expanded criteria thought best way to detect widest population with abnormal blood glucose levels.

Several population studies have demonstrated that when people are diagnosed with type 2 diabetes earlier in life, the risk of earlier complications including mortality related to the diabetes is significantly higher than in older populations.

Increased consumption of dietary sugars does not show increase risk of developing type 2 diabetes.

Identifying the lifestyle behaviors that can reduce the risk of type 2 diabetes in individuals considered low-risk.

Weight loss between young adulthood and midlife found to create statistically significant reductions in risk for diabetes.