Type 2 Diabetes

  In this week’s Homerun Slides, we continue our series from Dr. Stanley Schwartz, with a focus on some of the treatments drugs including metformin, pioglitazone, and the glp-1 agonists….

A potential new treatment option for T2 diabetes…. 

David Joffe, BSPharm, CDE, Editor-in-chief, Diabetes In Control In 2003, the Treat to Target Trial study results were published. The study compared the effectiveness of a patient mediated titration schedule with both NPH and glargine, and also whether patient titration was as good as a prescriber-based titration….

Exenatide, a GLP-1 receptor agonist, improves glycemic control and body weight with twice daily or once weekly subcutaneous (SC) injections in patients with type 2 diabetes (T2DM)….

Type 2 diabetes mellitus (T2DM) often requires combination therapy to maintain glycemic control. Adding a sulfonylurea to metformin therapy improves glycemic control, but can cause hypoglycemia and weight gain. This 2-yr double-blind trial investigated the long-term efficacy and safety of adding linagliptin or glimepiride to ongoing metformin to treat T2DM….

This randomized, open-label, parallel-group, multicenter, 24-wk main treatment study, followed by a variable extension of at least 52 wk, compared the efficacy and safety of lixisenatide 20 µg QD and exenatide 10 µg BID in 634 T2DM patients insufficiently controlled on metformin ≥1.5 g/day (mean age 57.4 yr, diabetes duration …

The cardiovascular (CV) benefit of glucose lowering, particularly if too intensive, in type 2 diabetes mellitus (T2DM) is currently debated. Some modalities have even been reported, unexpectedly, to be associated with worse CV outcomes. To investigate the CV profile of the novel DPP-4 inhibitor linagliptin, a pre-specified meta-analysis of all …

For the complete article, Disease Progression in Type 2 Diabetes, and information on other aspects of GLP-1 treatment, please visit Novo Nordisk’s diabetesinamerica at www.novomedlink.com/diabetes/diabetes-in-america.

I saw an obese long-term person with Type 2 diabetes who was experiencing widely fluctuating BGs and had had two hospitalizations within the previous six months, one for a BG of 28mg dl and one for an infested hair follicle (BG 413 mg/dl in ER)….