Type 2 Diabetes

In the 24-week study, improved HbA1c and cholesterol reduced the need for medications…   Type 2 diabetes patients are often advised to make dietary decisions that are high in carbohydrates and low in fat and protein. Increased carbohydrates lead to high postprandial glucose readings. Due to this, there is interest …

In patients at high risk of cardiovascular disease, the risk of diabetes was over three times higher in those with increased serum calcium levels… Calcium is needed for the release of insulin to respond to higher amounts of blood glucose. It is possible that if serum calcium is not well …

The addition of a DPP-4 inhibitor decreased HbA1C while not requiring an increase in insulin, and subjects remained weight neutral without experiencing an increase in hypoglycemic events… Currently approved dipeptidyl peptidase-4 (DPP-4) inhibitors include alogliptin, linagliptin, saxagliptin, sitagliptin and vildagliptin. DPP-4 inhibitors work by enhancing glucose dependent insulin secretion and …

Type 2 diabetes patients were more likely to have lower stress reactivity and impaired stress recovery when compared to healthy subjects… Stress-related factors are thought to play a role in the development of type 2 diabetes. Such factors have an impact on metabolic, cardiovascular and inflammatory regulation. Previous studies have …

Use of blue LED light activates sulfonylureas… The use of sulfonylureas has long been an option for controlling type 2 diabetes. Their use is often associated with hypoglycemia and weight gain. A new technology seeks to minimize these side effects. Researchers are looking at a prototype sulfonylurea, JB253, which stimulates …

Yohimbine, a α2A-adrenergic receptor agonist, showed a 29% increase in insulin secretion in patients with type 2 diabetes related to the genetic variation… The feasibility of exploiting genomic information for individualized treatment of polygenic diseases remains uncertain. A genetic variant in ADRA2A, which encodes the α2A-adrenergic receptor (α2AAR), was recently associated with type …

In an analysis using genetic data from over 25 different studies involving diabetes patients, researchers can find no causal association between higher vitamin D levels and lower diabetes risk… Low circulating concentrations of 25-hydroxyvitamin D (25[OH]D), a marker of vitamin D status, have been associated with an increased risk of …

  Socioeconomic status plays a role in how strong the association is…. Previous studies have shown an association between working longer hours and risk factors that can contribute to type 2 diabetes incidence. These risk factors included physical inactivity, unhealthy lifestyle, poor nutritional choices, and cardiovascular disease. Other studies have …

  SGLT-2 inhibitor use in the management of glucose in type 2 diabetes could reduce blood pressure in patients with hypertension…. In a new study, researchers found that empagliflozin lowered blood pressure in patients with type 2 diabetes and hypertension. Hypertension affects about two-thirds of patients with diabetes. See more …

Typically when we diagnose a type 2 patient we start on the normal pathway of metformin and “diet and exercise” modifications. For many of our patients this regimen makes a significant improvement in their glucose levels and A1c values…. But for those patients who don’t improve, we are then forced …