Study suggests extreme calorie reduction may have same effect as bariatric surgery.

In this week's Homerun Slides, the philosophy for the reduced need for insulin in type 2 patients and the potential benefits of combining GLP-1-based therapies with insulin.

Male, 72 years of age, type 2, insulin requiring diabetes, also taking SGLT-2. Annual physical. No urinary complaints during the visit. Received annual lab work end of work day, glucose elevated much higher than he reports. WBC elevated, 1200, no urine culture, but U/A did show cloudy, leukocyte esterase 2+, wbc >60 H, bacteria many (>50) H, RBC 3-10, H.

A critical requirement for orderly epidemiologic, genetic and clinical research, and indeed for the management of diabetes mellitus and other forms of glucose intolerance is an appropriate classification system. Furthermore, a hallmark in the process of understanding the etiology of a disease and studying its natural history is the ability to identify and differentiate its various forms and place them into a rational etiopathologic framework.

Diet containing foods high in antioxidants found to reduce risk of stroke.

Longer duration of breastfeeding showed correlation with reduction of type 2 risk.

Treatment improves insulin sensitivity, lowers risk of heart and kidney disease.

Evidence shows cardio-protective ability beyond glucose-lowering mechanism of action.

Diabetes patients tend to overestimate complications risk, treatment benefits.

In the Look AHEAD study, about 15% had symptoms of mild–moderate depression, about 17% were current users of antidepressant medication, and about 4% both [13]. Other studies in the USA have described higher rates, up to 25%, of more severe depression, with all ethnic groups (white, African-American, Latinos and others) recording similar rates.