Phase-3 study to evaluate efficacy and safety of ertugliflozin monotherapy.

A new study suggests that people who spend time walking or even just standing instead of sitting may be at lower risk of type 2 diabetes.

Hypoglycemia is a potential side effect of which of the following classes of drugs: 1) Insulins 2) Sulfonylureas 3) Meglitinides 4) Amylin mimetics 5) All of the above Follow the link to see the right answer!

Woman, type 1 diabetes, 63 years of age. Well-educated diabetes wise. Reached out to me saying: "HELP!! Normally I take 10 units of Toujeo at 9 pm. I did that last night. This morning I meant to take an additional 2 units because I'm not getting any exercise due to a knee injury. By mistake I took my usual dose of 10 units." Before I read the rest of her email, I thought, I know her. She knows what to do. She wears a CGM, she’ll be watching that. Then I read on...

In this week's Homerun Slides, the ratios of the adverse events in patients and their tolerability of the placebo vs empagliflozin.

PI-3 kinase pathways: regulation of metabolism and gene expression: Signal transduction for insulin’s metabolic effects also diverges from insulin receptor substrate proteins and proceeds via the PI-3 kinase pathway. The first committed step involves type 1A PI-3 kinase, a heterodimer consisting of a p85 regulatory subunit and a p110 catalytic subunit. In quiescent cells, the regulatory subunit maintains a state of low activity for the catalytic subunit.

The use of a high protein diet instead of a high carbohydrate diet to help reverse the progression to diabetes.

Two studies show use of sensor implanted under skin that continuously monitors glucose levels resulted in improved levels in T1 patients who inject insulin multiple times a day.

Study shows significant improvement in diabetes control with a 1 point drop in A1c with less hypoglycemia.

Pioglitazone in people with insulin resistance, prediabetes or diabetes is associated with a decreased risk for major adverse cardiovascular events, study data shows.