DPP-4 Inhibitors offer some advantages over existing oral options for the management of type 2 diabetes such as a negligible risk of hypoglycemia compared with sulfonylureas and, in general, a weight-neutral profile.

Forms, dosages and dosing considerations for pregnancy, breastfeeding, hepatic and renal.

In 2016, the TYK questions that received the most interest from our readers were those with a personal touch: questions that gave case-study style descriptions of individual patients and their needs. The 5 most popular questions of the year are featured in this issue. Can you guess which of these 2016 TYK questions was the most popular of all? A. Question #814, January 2: Unnamed patient B. Question #817, January 23: Mrs. O'Doole C. Question #823, March 5: Mrs. Hunter D. Question #833, May 14: Mrs. Wilson E. Question #835, May 26: Mr. Fontello

You can view the top 5 questions of 2016 in one page here.

In a year that saw much discussion about new drugs, new devices, and how politics might affect medical care, the surveys you were most interested in were those that touched on the core aspects of care for patients with diabetes. See the five polls that engaged you most.

Data from 2 trials show long-term use can improve albumin/creatinine ratio, but not other renal outcomes.

New study finds that when you lose weight, you will consume more calories than necessary to maintain the lower weight.

One type of belly fat may be more risky, according to results from an imaging-based study.

Greater risk reduction in those not receiving antihyperglycemic treatment.

Diabetes increased modestly in general.