Systemic shift in glucose metabolism from oxidative phosphorylation to aerobic glycolysis

Increased obesity for men, women living in medium, small versus large metropolitan statistical areas

Half of meds ID'd in expanded access programs treat cancer; others for metabolic, endocrine diseases

Target HbA1c 7% to 8% for most patients with T2DM; deintensification of tx with HbA1c <6.5%

Latinos, African-Americans with recent-onset disease have higher risk than those with long-term disease

Disparities persisted for most foods and nutrients; worsened for processed meats, added sugars

Six of 18 systems met predetermined accuracy standard in three of three studies

Single-sample confirmatory definition associated with high positive predictive value

Longer sleep duration, greater efficiency linked to better metabolic risk scores in adolescents

Independently linked to major cardiovascular events, especially heart failure hospitalization