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Lifestyle-based weight loss intervention trials achieve modest reductions in weight and glycated hemoglobin (HbA1c) levels, according to a meta-analysis. From six studies comparing lifestyle intervention with usual care, the researchers found the pooled effect on weight (5,795 patients) to be −3.33 kg, and −0.29% on HbA1c (5,784 patients), with both …

Combo Drug Glyxambi is a combination of empagliflozin and linagliptin in a tablet form for adults with type 2 diabetes. Both empagliflozin, an SGLT-2, and linagliptin, a DPP-4 inhibitor, are already on the market separately. Glyxambi’s main benefit is combining two different diabetes drugs into a single pill (in this …

Obesity is costly. Some of those costs are surprising ($2.5 billion wasted in gasoline). Others represent true injustice (obese black women earn 34% less than the rest of the workforce). But as significant as these diverse amounts are, they are almost incidental in comparison to the health care costs resulting …

A retrospective study of patients with type 2 diabetes taking metformin and sulfonylureas and newly treated with either a dipeptidyl peptidase 4 (DPP-4) inhibitor or insulin as third-line therapy has found that adding insulin was associated with an increased risk of cardiovascular events compared with a DPP-4 inhibitor. For the …

Children with type 2 diabetes had worse glycemic control, more hypertension and higher BMI’s when their parents had diabetes, hypertension and obesity, according to new research. Researchers looked at 699 children with type 2 diabetes and found that those whose parents had diabetes had higher baseline A1C levels and were …

High HbA1c, high-fasting glucose and impaired oral glucose tolerance are related to lower cardiorespiratory fitness levels, according to recent findings. Cardiorespiratory fitness also appears to be associated with pancreatic beta-cell insulin secretory compensation for changing insulin sensitivity. “The association provides additional evidence highlighting the importance of fitness in protection against …

Overweight individuals who were asked to walk on a treadmill for 15 minutes had lower cravings for sugary snacks than those who did not exercise, Austrian researchers reported in the journal PLOS ONE. European Journal of Endocrinology, March 2015  

Taking at least two courses of prescribed antibiotics was associated with a higher risk of developing type 2 diabetes, according to a new study. The likelihood of getting diabetes increased by 8% after receiving two to five courses of penicillin. For patients who took two to five courses of quinolones, …

A study in Diabetes Care found fewer life years and greater health care expenses linked to diabetes. For individuals with diabetes, the predicted life expectancy had an inverted U-shape for most BMI classifications, with overweight individuals having the highest life years lost. Higher lifelong health costs were seen in whites and …

Australian researchers found a higher odds of eliminating symptoms of atrial fibrillation in obese patients who lost at least 10% of their body weight without undergoing surgery or medication than in those who failed to lose weight. The findings were presented at the American College of Cardiology meeting. — Journal …