January 31, 2017 : DCMS #330

DISASTERS AVERTED — Near Miss Case Studies

Life Happens to Our Patients Too. Be Understanding.

EXCLUSIVE INTERVIEW — Candid Video Interviews with Top Practitioners

Altamash Shaikh Part 4, The Diabetes Solution

HOMERUN SLIDES — Great Clinical Presentation Highlights

EMPA-REG Outcome Trial, Part 7

CLINICAL GEMS — The Best from Diabetes Texts

International Textbook of Diabetes Mellitus, 4th Ed., Excerpt #60: Mechanisms of Insulin Signal Transduction Part 4 of 8

MOST POPULAR ARTICLES OF THE MONTH

#1 New ADA 2017 Standards of Medical Care in Diabetes
#2 Remission of Prediabetes to Normal Glucose Tolerance in Obese Adults
#3 Preventing CV Death in Patients With Diabetes

Dave Joffe

Editor-in-chief

Woman, type 1 diabetes, 63 years of age. Well-educated diabetes wise. Reached out to me saying:

“HELP!! Normally I take 10 units of Toujeo at 9 pm. I did that last night. This morning I meant to take an additional 2 units because I’m not getting any exercise due to a knee injury. By mistake I took my usual dose of 10 units.”

Before I read the rest of her email, I thought, I know her. She knows what to do. She wears a CGM, she’ll be watching that. Then I read on…

Dr. Altamash Shaikh talks with Diabetes in Control Associate Medical Editor Joy Pape at the 2016 AACE Meeting. In part 4, the conclusion of this Exclusive Interview, Dr. Shaikh gives his thoughts on solving the diabetes problem in the Indian community.

In this week’s Homerun Slides, the ratios of the adverse events in patients and their tolerability of the placebo vs empagliflozin.

PI-3 kinase pathways: regulation of metabolism and gene expression: Signal transduction for insulin’s metabolic effects also diverges from insulin receptor substrate proteins and proceeds via the PI-3 kinase pathway. The first committed step involves type 1A PI-3 kinase, a heterodimer consisting of a p85 regulatory subunit and a p110 catalytic subunit. In quiescent cells, the regulatory subunit maintains a state of low activity for the catalytic subunit.

Psychological health, access to care, expanded and personalized treatment options and the tracking of hypoglycemia emphasized.

The use of a high protein diet instead of a high carbohydrate diet to help reverse the progression to diabetes.

What do we need to tell our patients about preventing the risk for death?