August 27, 2016 : Issue #848

• Impact of Carbohydrates in Diabetes Patients
• C-Peptide Levels in Diabetes Management
• Delaying Parkinson’s Disease Onset with Statin Therapy
• Understanding Metabolic Effects of Obesity In Patients with Type 2 Diabetes
• Engaging Patients In Diabetes Management
• How Much Exercise Compensates for Sitting at a Desk Eight Hours A Day?

Last week in our Clinical Series we had an excerpt from International Textbook of Diabetes Mellitus, 4th Ed., looking at Beta-Cell response to nonglucose secretagogues. This text dealt with how the beta cells might be affected by more than just glucose. We are learning more about how fat. protein, and non-insulin peptides might have effects we had never thought of.

We begin this newsletter with powerful information on how these low carb, higher fat, higher protein diets may benefit A1c at the risk of aggravating other conditions. Our second item looks at using one of the peptides associated with natural insulin production and activation alone to reduce A1c and random glucose readings in type 1 patients.

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We can make a difference!

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Dave Joffe, Editor-in-chief

FDA requests, receives more data for iGlarLixi combination pen: The FDA has requested and received additional information regarding pen delivery service for glargine and lixisenatide injection. An approval decision on the medication is expected in November.

How often do you prescribe or recommend a sulfonylurea for a new type 2 patient?
1) Often
2) About 50%
3) Almost Never

Follow the link to share your opinion!

Would you know what to do in a diabetic seizure emergency situation? There are simple solutions to ensuring you have what it takes to help a family member, co-worker, child, or stranger in need of emergency first aid.

Clinicians treating patients with type 2 diabetes should include lifestyle interventions when developing diabetes management plans. Which of the following is NOT appropriate?

1.Weight reduction, if necessary
2. A minimum of 150 minutes/week of moderate-intensity aerobic physical activity, spread over at least 3 days/week with no more than 2 consecutive days without exercise
3. Diabetes Self-Management Education & Support (DSME/DSMS)
4. A calorie fixed ADA diet
5. Individualized plan of calories including recommended amounts carbohydrates, fats, and proteins

Do you have the right answer? Follow the link to find out!

New research shows that exercise can reduce the risks for cancer, colon cancer, diabetes, ischemic heart disease and ischemic stroke. If there was a pill that could do that, it would cost more than any of our patients could afford. Imagine having a tool that costs nothing that can prevent at least five diseases and many more.

The data, from a total 174 studies comprising 149,184,285 total person-years of follow-up, suggest that the more total regular daily physical activity one engages in — including recreation, transportation, occupational activity, and/or daily chores — the lower the risks for many diseases. However, significant reductions in those conditions were seen only with total activity levels considerably higher than the minimum 600 metabolic equivalent (MET) minutes per week recommended by the World Health Organization for health benefits. (600 METs equates to about 150 minutes/week of brisk walking or similar activity in other physical activity.)

Another recent meta-analysis of trials involving more than one million individuals indicated that an hour of moderate-intensity activity, such as brisk walking or cycling, offsets the health risks of 8 hours of sitting. The message that physical inactivity is a killer — leading to 5.3 million premature deaths annually worldwide, which is as many as caused by smoking and twice as many as associated with obesity — has been emerging over the past few years, with warnings that “sitting is the new smoking.”

Findings from the systematic review and meta-analysis were published online August 9 in the BMJ by Hmwe H Kyu, PhD, of the University of Washington, Seattle, and colleagues.

Are very-low carbohydrate, low saturated fat diets the best choice for A1c control?

Can C-peptide help attain adequate glycemic control in diabetes patients?

Can statins provide neuroprotective properties in diabetes patients?

What is the association between obesity and cardiovascular risks?

How can diabetes progression be prevented in patients with nondiabetic hyperglycemia?

At least an hour of physical activity needed to offset risk for several chronic conditions and mortality.

Quote of the Week!

“Exercise to stimulate, not to annihilate. The world wasn’t formed in a day, and neither were we. Set small goals and build upon them.”

…Lee Haney

Diabetes in Control gratefully acknowledges the assistance of the following pharmacy doctoral candidates in the preparation of this week’s newsletter:

Pablo A. Marrero-Núñez, USF College of Pharmacy

Your Friends in Diabetes Care
Steve and Dave
Diabetes In Control
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Ewing, NJ, 08628
USA
www.diabetesincontrol.com