Multiple Pregnancies May Increase Risk of Obesity, Diabetes

Multiple pregnancies may increase the risk of obesity, diabetes and the buildup of plaque in the arteries, suggests new research in mice. Scientists from the University of Cincinnati and colleagues studied mice late in gestation in either their first or fourth pregnancy. Those in their fourth pregnancy had severe glucose intolerance and excess fat tissue, while those in their first pregnancy did not have glucose intolerance and had less fat. In addition, the fat tissue in mice in their fourth pregnancy had significant increases in several inflammation-causing chemicals called cytokines and an accumulation of inflammation-related white blood cells called macrophages. Repeated cytokine fluctuations during pregnancy may cause residual inflammation that affects cardiovascular health, according to the study. If such changes also occur in humans, women who have multiple pregnancies may be at increased risk for plaque buildup in the arteries, obesity and diabetes, the researchers concluded. Presented at the Arteriosclerosis, Thrombosis and Vascular Biology April 2011 Scientific Sessions