Man, 52 years of age, with obesity and type 2 diabetes, was switched from daily liraglutide (Victoza) 1.8mg to weekly semaglutide (Ozempic) 0.25mg. I was very clear with patient about the switch being from a daily injection to a weekly and that we would be increasing the semaglutide weekly.

In this week's Homerun Slides, a closer look at the Systolic Blood Pressure Intervention Trial (SPRINT).

The foregoing observations have detailed the best established risk factors associated with insulin resistance as well some novel emerging risk factors as additionally detailed in Table 23.2, including nutritional measures such as Vitamin D. These are not comprehensive but rather a selection of emerging pathways of interest. Clearly, future research should increasingly harness genetics as well as observational data to better determine causal risk pathways. Similarly, further data are needed to better determine the extent to which insulin resistance is, or is not, linked to cardiovascular risk.

Here are what the editors at HealthDay consider to be the most important developments in Diabetes & Endocrinology for April 2018. This roundup includes the latest research news from journal articles, as well as the FDA approvals and regulatory changes that are the most likely to affect clinical practice.Review: Need …

Major adverse CV and cerebrovascular events with noncardiac sx have also increased in DM patients

Findings show MHO is transient, so not a reliable predictor of lower cardiovascular risk in the future

Frequency of primary outcome was 27.6 and 23.4 percent in glyburide and insulin groups, respectively

High testosterone levels seen, indicating underlying polycystic ovary syndrome could be a cause

Position paper offers guidance for strengthening methods for assessing natural experiments

I was having dinner with a group of cycling couples recently We are all participating in the Bike Virginia 6-day riding event in late June and we were discussing travel plans. One of the participants is an optometrist and we got into a discussion about prescription sunglasses for the ride. …