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Daily Archives: Oct 23, 2018

Oct. 23, 2018

More and more clinicians are recommending low carb food programs for both the prevention and treatment of diabetes. This swing has led toward the consumption of more red meat and processed meats, which may actually have the opposite effect for our patients. This may happen because processed meats such as …

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What Not to Trust

I received a call and glucose numbers from patient who has type 2 diabetes, usually with hyperglycemia, never hypoglycemia. I noticed there was at least a 12-hour span since the last glucose reading. His glucose levels after the over-12-hour lag showed hypoglycemia during the  night when the numbers start showing. His glucose averaged 53 during that time, but it has been running 150 and over, and we have been slowly increasing his insulin.

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Sylvia Ley Complete Interview

Sylvia H Ley, PhD, RD is a Research Scientist at Harvard T.H. Chan School of Public Health and Associate Epidemiologist and Instructor at Brigham & Women’s Hospital and Harvard Medical School. Her overall research objectives are to develop the dietary strategies to prevent and manage diabetes and to investigate earlier life reproductive risk factors for diabetes and cardiovascular disease over the lifecourse.

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International Textbook of Diabetes Mellitus, 4th Ed., Excerpt #148: Glucose Toxicity Part 4

The hexosamine/O-linked N-acetyl glucosamine pathway: One metabolic fate of glucose is the hexosamine biosynthetic pathway (HBP), and high flux through this pathway, such as occurs in diabetes or overnutrition, has been convincingly linked to insulin resistance and beta-cell failure. In this pathway a relatively small fraction of cellular glucose flux—a few percent in most tissues—is converted to UDP-N-acetylglucosamine (UDP-GlcNAc) and other amino sugars. The rate limiting step is catalyzed by the enzyme glutamine: fructose-6-phosphate amidotransferase (GFA) that catalyzes the synthesis of glucosamine-6-P from fructose-6-P and glutamine.

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