High density mapping: GWAS do not inevitably lead to identification of a gene or genes in a given locus associated with disease.The most strongly associated SNPs are often only markers for the functional variant responsible for the observed genetic effect and most associated regions harbor several genes. Therefore, additional fine mapping of the loci in even larger sample sets is often necessary. To do this cost-efficiently a Cardio-Metabochip has been developed for metabolic/cardiovascular gene mapping. This custom-design Illumina Infinium genotyping chip contains ∼200,000 polymorphisms selected to cover association signals from a wide range of metabolic disorders (T2DM, lipid disorders, obesity, and cardiovascular disease), was designed to perform both deep replication of major disease signals and fine mapping of established loci. Meta-analysis of previous GWAS with an additional 22,669 T2DM cases and 58,119 controls genotyped using the Cardio-Metabochip has recently added another eight new loci associated with T2DM in the European population

In this Exclusive Interview transcript, Dr. Alpana Shukla talks about Food Order studies and the dramatic impact eating carbs last during meals can have on blood glucose levels and other indicators.

In this Exclusive Interview, Alpana Shukla talks with Diabetes in Control Medical Editor Joy Pape during the ADA 2018 convention in Orlando about the Food Order Study.

In part 1 of this Exclusive Interview, Alpana Shukla talks with Diabetes in Control Medical Editor Joy Pape about the purpose and findings in the Food Order Studies.

In part 2 of this Exclusive Interview, Alpana Shukla talks with Diabetes in Control Medical Editor Joy Pape about the differences between the real-world food order study and protein preloading.

In part 3 of this Exclusive Interview, Alpana Shukla talks with Diabetes in Control Medical Editor Joy Pape about the relevance of the study for people with any type of diabetes or no diabetes.

In part 4 of this Exclusive Interview, Alpana Shukla talks with Diabetes in Control Medical Editor Joy Pape about the effects of food order on satiety and weight management.

In part 5, the conclusion of this Exclusive Interview, Alpana Shukla talks with Diabetes in Control Medical Editor Joy Pape about the future of this research and plans for the next study.

Racial/ethnic differences seen in the association of aldosterone with incident type 2 diabetes

All determinants also associated with bone mineral density, which showed causal effect on fracture