Gluconeogenic pathways: Gluconeogenesis is the synthesis of glucose from three carbon precursors such as alanine, pyruvate, lactate, and glycerol and is essentially a reversal of glycolysis. Under normal conditions, 90% of gluconeogenesis occurs in liver, and the rest occurs mainly in the renal cortex. Other sites of gluconeogenesis, such as the small intestine have been suggested but remain controversial.

Most of the time when we speak about patients who are not diagnosed with diabetes and who develop complications, we are usually referring to vision changes or things like neuropathy. However, it now appears that there are a good number of these undiagnosed who die from ketoacidosis. This week, our …

New evidence questions the idea of what is normal.

A new finding from the SCALE trial.

Gastric bypass surgery may treat type 2 diabetes in selected patients.

Changes in serum metabolomic profile affect eGFR in patients with type 1 diabetes.

Genetic predisposition to a higher waist-to-hip ratio may lead to diabetes.

Proponents may suggest an advantage of one over the other, but the data is not so clear.

The diabetes drug empagliflozin reduces all of the following CV risk factors except: a. Blood pressure b. Visceral adiposity c. Low-density lipoprotein cholesterol d. Triglycerides e. Atrial stiffness Follow the link to see if you got it right!

Should physicians be able to help patients end their lives? Follow the link to share your opinion and see what your colleagues say.