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Yearly Archives: 2017

International Textbook of Diabetes Mellitus, 4th Ed., Excerpt #72: Regulation of Glucose Metabolism in Liver Part 8 of 11

Linking molecular and metabolic regulation of hepatic glucose metabolism: Cross-talk between metabolism and molecular biology is an emerging mechanism of metabolic regulation and is particularly relevant to the control glucose metabolism in liver. Some transcription factors and nuclear receptors are activated in response to metabolites. During fasting lipid metabolites are released that activate PPARα and induce the gene expression of oxidative metabolism.

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April 22, 2017

For many years, we never really gave great concern to the micro- and macrovascular problems in type 2 patients. Most of them were not diagnosed until they were in their late 50’s or early 60’s, and they did not really live long enough to develop severe problems. Now that diabetes …

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