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Yearly Archives: 2017

International Textbook of Diabetes Mellitus, 4th Ed., Excerpt #59: Mechanisms of insulin signal transduction Part 3 of 8

Insulin receptor substrate molecules -- receptor substrate/docking protein: Following insulin binding and receptor autophosphorylation, the next committed step in signal transduction is tyrosine phosphorylation of intracellular proteins. To accomplish this, autophosphorylation of the beta subunit mediates noncovalent but stable interactions between the receptor and intracellular substrate proteins, and this positions these molecules for tyrosine phosphorylation by the activated insulin receptor kinase.

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Jan. 21, 2017

It seems that we are finally acknowledging that preventing diabetes is an idea that may be worthwhile. This week, we have a feature about how to predict which children will develop diabetes in their lifetime. This gives us an earlier place to start treating prediabetes. We also can start testing …

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