When it comes to diabetes, there seems to be a thousand right ways to get your patients to lose weight. While weight loss is only one component of managing diabetes, it is often the most quoted and hardest to do. This week in Part 4 of our Exclusive Interview with …

In part 4 of this Exclusive Interview, Dr. Karl Nadolsky talks with Diabetes in Control Publisher Steve Freed during the AACE 2017 convention in Austin, Texas. Dr. Nadolsky explains his preferences for patients when discussing weight loss.

In this week's Homerun Slides, the implications of new guidelines for the preservation of beta cells.

Insulin action dynamics: Insulin sensitivity from the clamp is expressed in terms of the steady-state value reached after a period of hyperinsulinemia. A dose–response can be constructed and sensitivity can be expressed as the ED50, that is, the concentration for half-maximal stimulation of Rd as a function of dose. Alternatively, sensitivity can be expressed (as it usually is) as the Rd at a specific dose of insulin, which may be low, intermediate, or a maximum dose. It is often assumed that steady-state rate of glucose uptake is reached by 180 min after onset of the insulin infusion. In fact, steady-state glucose uptake is not reached at 3h. Glucose uptake rate at 3h is only 2/3 the “true” steady-state, which is not achieved until 6h. Certainly, shorter periods (e.g. 120 min) are inadequate to reflect steady-state rates of uptake.