Amin Zayani discusses insulin safety and how the path to creation of the Medangel ONE app for insulin temperature monitoring began when his refrigerator accidentally froze his insulin and made it completely useless.

Amin Zayani talks with Diabetes in Control Publisher Steve Freed during the ADA 77th Scientific Session in San Diego about why MedAngel ONE can effectively help patients with diabetes ensure the safety of their insulin and avoid the financial burden of having to replace damaged insulin.

Amin Zayani talks with Diabetes in Control Publisher Steve Freed during the ADA 77th Scientific Session in San Diego about the potential for other ways his product, MedAngel, could be useful to the person who is managing their diabetes with insulin.

Why is your fridge a frenemy of your insulin? Amin Zayani explains in a talk with Diabetes in Control Publisher Steve Freed during the ADA 77th Scientific Session in San Diego.

Amin Zayani shares the inspiration for his new product to protect insulin with Diabetes in Control Publisher Steve Freed during the ADA 77th Scientific Session in San Diego.

Many times when we least expect it there is a past and present combination in diabetes. This week in our Clinical text we start a discussion on the idea of measuring in vivo insulin. It was back in 1925 when Banting and Best first gave insulin to reduce glucose levels. …

Man, 76 years of age, type 2 diabetes, obesity, SP right total hip replacement one year out. When preparing for hip surgery, was on basal and bolus insulin, metformin. Had been on a GLP-1 but had diarrhea so he stopped. Was able to, for the most part, follow a lower carbohydrate meal plan but was not active. When he first started coming to us for weight loss to prepare for his surgery, his weight was 304 pounds, BMI 45, A1c 9.9%, Cr 1.87, eGFR 34. We decreased his metformin from 2,000mg/day to 1,000mg day and referred to nephrology. With this change and being motivated for surgery, he lost weight and in 6 months went into surgery having lost 25 pounds with an A1c of 6.9%. Note, due to eating less carbs, he could take less insulin, which seemed to help his appetite. Surgery was performed and he did well.

In part 2 of this Exclusive Interview, Dr. Karl Nadolsky talks with Diabetes in Control Publisher Steve Freed during the AACE 2017 convention in Austin, Texas about the importance of using BMI when determining an obesity treatment plan.

In this week's Homerun Slides, insulin resistance within the beta-cell centric construct.

The heralded isolation of insulin in Toronto in 1921 was followed immediately by treatment of diabetes. It soon became clear that while insulin was effective in regulating the blood glucose levels in most patients, there were some subjects in whom insulin appeared to be ineffective. This lack of insulin effect was termed “insulin resistance” as early as 1925.