We all make the assumption that insulin resistance comes from eating too much glucose. However, for many patients, this resistance occurs because they release too much insulin. This can be environmentally related or it can be blamed on heredity. Regardless of the cause, this hyperinsulinemia can result in long-lasting effects …

23-year-old female, type 1 diabetes since 5 years of age. A1C elevated to 8.9% after usually having A1Cs in the 6-7 range. Came to see me at the end of our workday after wearing LibrePro (Blinded CGM) to go over her food/insulin/glucose/activity/etc. patterns. First thing she said to me was that she had a Dexcom but hasn't worn it because battery in transmitter was out for the past 6 months. She told me she really hasn't been checking her glucose on a regular basis at all.

In part 6 of this Exclusive Interview, understanding how a parent or caregiver can monitor an adolescent who is using the system.

In this week's Homerun Slides, the effects of hyperinsulinism.

Glucose phosphorylation as a therapeutic target for diabetes: Early experiments using genetic overexpression of glucokinase in liver of rodent models showed promise for the protection against hyperglycemia during diabetes, spawning the development of glucokinase activators. These drugs interact with allosteric sites of glucokinase, thus promoting a conformation that exposes the catalytic domain and potentiates the activity of the enzyme.