In this week's Homerun Slides, the conclusion of type 2 diabetes management strategies. Two case studies show the role of DPP-4 and SGLT-2/DPP-4 combo treatments.

Physiologic effects of glucagon: Glucagon acts through binding to specific receptors located at the target cell plasma membrane. The major common effect of glucagon is to activate adenylate cyclase and to increase the intracellular production of cAMP. There is considerable evidence that binding of glucagon to its receptor activates an intermediate transduction process that involves the participation of guanosine triphosphate (GTP), divalent cations, and adenosine (or other similar natural substances).