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Daily Archives: Jun 14, 2016

June 14, 2016

We are at the ADA in New Orleans and as I was looking over the posters, there was a whole section focused on Gene Expression and Biosynthesis. There were multiple small population projects on what might cause the mutations and proposed mechanisms to fix  or prevent the problems that these …

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International Textbook of Diabetes Mellitus, 4th Ed., Excerpt #28: Insulin Gene Expression and Biosynthesis Part 4 of 6

Insulin biosynthesis: the previous section outlines that insulin gene transcription is a highly controlled process. The product of this process, pre-proinsulin mRNA, is unusually stable in pancreatic beta cells and it is further stabilized as glucose concentrations increase. As such, there is normally an abundant source of preproinsulin mRNA in the beta-cell cytosol available for translation.

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