It has been two years since the first SGLT-2 inhibitor, canaglifozin, was approved by the FDA. Since that approval, two more drugs in this class have been approved and the acceptance and use by medical professionals has widened. The mechanism of this class is unique as it works directly on …

The recent study “Diet Soda Intake Is Associated with Long-Term Increases in Waist Circumference in a Biethnic Cohort of Older Adults: The San Antonio Longitudinal Study of Aging (SALSA)”1 suffers from several limitations, which likely confound the study’s conclusions. The authors note that the waist circumference (abdominal fat) findings were not …

In the meta-analysis of 14 randomized trials, DPP-4 inhibitors were also found to increase cardiovascular risk slightly while the effect of insulin glargine was neutral…. Data was reviewed from 14 randomized controlled trials of 95,502 patients with or at risk for type 2 diabetes taking new or more intensive glucose-lowering …

A greater muscle to total abdominal area ratio was associated with lower odds of diabetes…. Skeletal muscle loss with diabetes onset is common and low muscle mass can be a potential risk factor for diabetes. Studies show that glucose storage and consumption by lean muscle are important factors when looking …

An increase in polyunsaturated fatty acid intake showed some benefit in pregnant women with GDM as well as the fetus… GDM not only puts mothers at risk but it can also be dangerous for infants. Studies show that more than half of pregnant women with GDM develop overt diabetes within …

The prevalence of obesity, diabetes, and new onset diabetes continue to grow…

The results of insulin release and glucose tolerance across a sample with declining kidney function… Insulin resistance is not uncommon to see when looking at patients with declining kidney function or chronic kidney disease (CKD). Insulin resistance progressively worsens with respect to kidney function decline. Although insulin resistance and chronic …

Diabetics who drink coffee had significantly lower HbA1c and higher adiponectin compared to those who did not… Researchers from India and Trinidad studied the levels of adiponectin in coffee drinkers for type 2 diabetes (DM2) and non-diabetic patients. This was a cross-sectional study including 220 non-diabetic subjects, 143 of who …

In a screen of more than 100,000 potential drugs, only one, harmine, drove human insulin-producing beta cells to multiply… The Mount Sinai study found that harmine drove the sustained division and multiplication of adult human beta cells in culture. In addition, harmine treatment tripled the number of beta cells and …

Canagliflozin shows good results when compared to glimepiride in type 2 diabetes patients who were taking metformin.