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Handbook of Diabetes, 4th Ed., Excerpt #13: Control and Complications

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Rudy Bilous, MD, FRCP Richard Donnelly, MD, PHD, FRCP, FRACP   Much of the impact of chronic diabetes results from the development of tissue complications, mainly microvascular (retinopathy, nephropathy and neuropathy) and macrovascular disease (atherosclerosis). Microangiopathy is characterized by progressive occlusion of the capillary lumen with subsequent impaired tissue perfusion, increased vascular …

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