A recent study examined the relationship between sleep disorders and the risk of dementia in patients with newly diagnosed type 2 diabetes, and found sleep disorders had differential effects on subtypes of dementia. Sleep disorders increased the risk of Alzheimer’s disease but did not influence vascular dementia. Significant positive association between sleep disorders and Alzheimer’s disease was well established, but previous evidence for vascular dementia was unclear.
In the patients with type 2 diabetes with age range 42-84 (M=57.8, SD=9.5), this study identified 2,059 events of dementia during an average follow-up time of 5.7 years. In patients with type 2 diabetes, subjects with sleep disorders were associated with an increased risk of all-cause dementia, Alzheimer’s disease, and other dementias compared to those without sleep disorders. This study used the Korean Health Screening Cohort data and included 39,135 subjects aged ≥40 years with new-onset type 2 diabetes between 2004 and 2007, with follow-up throughout 2013. Sleep disorders were measured by ICD-10 code as a primary diagnosis, and the adjusted hazard ratio (AHR) and 95% CI of all-cause dementia, Alzheimer’s disease, vascular dementia, and other dementia were estimated using multivariable Cox proportional hazards regression models.
These findings suggest that sleep disorders are significantly associated with an increased risk of dementia in patients with new-onset type 2 diabetes.
J Diabetes. 2020 July 18. doi: 10.1111/1753-0407.13092. Online ahead of print