The oral glucose tolerance test has been the gold standard in diagnosing diabetes and prediabetes. Glycated Hemoglobin (HbA1c) has been used for some years to diagnose prediabetes and diabetes also, but is currently under extensive discussion for contradictory data on the concordance between this test and the oral glucose tolerance test (OGTT).   In order to assess the concordance between HbA1c and OGTT to diagnose prediabetes and diabetes in patients who have overweight or obesity the following study was done. A total of 949 outpatients with overweight or obesity at risk for diabetes (mean age 50 ± 15 years; 660 F) were enrolled and underwent HbA1c test and OGTT. From the results, they found that in both genders, HbA1c test identified more patients with prediabetes than OGTT (42% vs 22% in males, 40% vs 18% in females, respectively); a slight concordance between HbA1c and OGTT (60% of total tests in both genders).  In subjects diagnosed by OGTT, postOGTT insulin levels and HOMA INDEX were significantly higher than those found in HbA1c(+) cases. Instead, those diagnosed with HbA1c were significantly older and showed higher uric acid than those with both tests (−).  The results showed that the HbA1c test and OGTT did not reach full concordance for the diagnosis of diabetes and prediabetes in both genders. The two tests likely reflect different physiopathological aspects of dysglycemia, suggesting that the “diagnostic thresholds” could be reconsidered in light of the discordance observed.   Clin Endocrinol. 2019;91(3):411-416.