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Daily Archives: Mar 12, 2019

March 12, 2019

Years ago, we only had a couple of drugs for diabetes and we wanted more. Then, in the past 10 years, we have had an explosion of drugs and you can bet there are more coming soon. This week, Joy Pape sits down with Jeffery Emmick from Eli Lilly to …

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International Textbook of Diabetes Mellitus, 4th Ed., Excerpt #168: Molecular Genetics of Type 1 Diabetes Part 5

Linkage studies identify regions of the genome that are shared more frequently than would be expected by chance by relatives affected by a particular disease. Most studies analyze affected sibling pairs and utilize genetic markers that are scattered throughout the genome at moderate density, typically microsatellites. A significant excess of allele sharing identical by-descent (IBD) in affected sibpairs suggests that the region containing the marker locus also contains a disease susceptibility locus. The first linkage scan for T1DM identified 20 chromosomal regions with suggestive evidence of linkage to disease, including the HLA and INS gene regions.

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