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Monthly Archives: February 2019

Feb. 26, 2019

This week we have an interesting post-hoc article on the results of the Da Qing Diabetes study. This retrospective examination looks at how hypertension increases the risk for diabetes and how that in turn increases the risk for cardiovascular disease. There are great details that make this article worth reading, …

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Catherine Champagne 2018 Complete Interview

Catherine M. Champagne, PhD, RDN, LDN, FADA, FAND, FTOS  is a professor at the Pennington Biomedical Research Center at Louisiana State University. Dr. Champagne's research areas currently concentrate in studies which include dietary counseling and/or dietary intake assessment of subjects. She directs the Nutrient Database activities for the Center. She is also coordinator of the Women’s Nutrition Research Program at Pennington, a research, education, and outreach program specifically targeted to women.

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International Textbook of Diabetes Mellitus, 4th Ed., Excerpt #166: Molecular Genetics of Type 1 Diabetes Part 3

Other HLA-encoded susceptibility determinants: The DR and DQ genes cannot completely explain the association between T1DM and the HLA gene region. Teasing out the contribution of other HLA loci, however, is complicated by the high level of linkage disequilibrium within the region, combined with the strong effects of DR and DQ. A number of different approaches have been employed to address this issue, including the analysis of case/control data matched for specific DR-DQ combinations, investigation of the transmission to affected and unaffected offspring of heterozygous markers from parents homozygous for DR-DQ alleles, conditional logistic regression and conditional haplotype analysis.

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