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Daily Archives: Aug 28, 2018

Aug. 28, 2018

In our Saturday newsletter we had a great feature about how weight loss in certain patients can cause reversal of diabetes. This week in our Mastery newsletter, Medical Editor Joy Pape shares her candid interview with Dr. George Bray, Professor of Medicine Emeritus at LSU, that she did at the …

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Diabetes and/or Obesity: Whose Fault Is It?

Many people who have diabetes, especially type 2 diabetes, tell me they have no one to talk with about their diabetes. Why, with all the education and tools we have, do people who have diabetes still feel this way? My patients who have excess weight or obesity tell me the same thing. We may not have as much clinical information on that as we do diabetes as of yet, but the patients tell me the same thing.

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George Bray 2018 Complete Interview

George A. Bray, M.D., MACP, MACE is a Boyd Professor Emeritus at the Pennington Biomedical Research Center of Louisiana State University in Baton Rouge, Louisiana, and Professor of Medicine Emeritus at the Louisiana State University Medical Center in New Orleans.  After graduating from Brown University summa cum laude in 1953, Bray entered Harvard Medical School graduating magna cum laude in 1957. His post-doctoral training included an internship at The Johns Hopkins Hospital, Baltimore, MD, a fellowship at the NIH, residency at the Strong-Memorial Hospital, University of Rochester, a fellowship at the National Institute for Medical Research in London and at the Tufts-New England Medical Center in Boston.   In 1970, he became Director of the Clinical Research Center at the Harbor UCLA Medical Center, and organized of the First Fogarty International Center Conference on Obesity at NIH in 1973. Bray also Chaired the Second International Congress on Obesity in Washington DC in 1977. In 1989 he became the first Executive Director of the Pennington Biomedical Research Center in Baton Rouge, a post he held until 1999. He is a Master of the American College of Physicians, Master of the American College of Endocrinology and Master of the American Board of Obesity Medicine. Bray founded the North American Association for the Study of Obesity in 1982 (now The Obesity Society), and he was the founding editor of its journal, Obesity Research, as well as co-founder of the International Journal of Obesity and the first editor of Endocrine Practice, the official journal of the American College of Endocrinologists.

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International Textbook of Diabetes Mellitus, 4th Ed., Excerpt #140: The Genetics of Type 2 Diabetes Part 2

Heritability of T2DM: It has long been clear that T2DM clusters in families and it is well established that the risk of developing T2DM depends on both genetic and environmental factors. However, the exact proportion of the two, that is, the heritability, is difficult to determine and heritability estimates therefore vary in the range of 25–80% between studies. Twin-studies have estimated the genetic component by comparing disease concordance in dizygotic twins with concordance in monozygotic twins. In these studies probandwise concordance rates (number of affected twins having a diabetic co-twin) for monozygotic twins vary between 34 and 100%.

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