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Vitamin D Deficiency in Type 1 Diabetes Patients

Vitamin D supplementation for the prevention of the onset of type 1 diabetes is also being studied…. 

Research done on diabetic mice has found that mice deficient in vitamin D were at a higher risk of developing diabetes. Vitamin D has been found to play a role in the prevention of Type 1 diabetes. It was also found through the research on mice that early administration of vitamin D in combination with cyclosporine A while in a pre-diabetic state can prevent the onset of diabetes.

Observational studies in humans looking at the association between vitamin D and Type 1 diabetes found that there is a connection between vitamin D deficiency and Type 1 diabetes. There was higher prevalence of Type 1 diabetic patients in those who had a vitamin D deficiency. A cross-sectional study done in Switzerland found that 60-84% of Type 1 diabetics were vitamin D deficient. A case-control study completed in Qatar looking at both Type 1 diabetic and non-diabetic children with deficiencies in vitamin D found that 90.6% of the Type 1 patients were deficient compared to 85.3% on non-diabetics. Only one study completed in Florida found no difference in vitamin D levels in diabetes compared to controls.

A pilot study completed looking at both Type 1 and 2 diabetics comparing vitamin D deficiencies found a greater prevalence of the deficiency in the Type 2 diabetics. This study also found that the Type 2 diabetics had a greater deficiency of vitamin D independent of age, sex, BMI and insulin treatment.

Through the studies completed in humans it has been found that there is a high prevalence of vitamin D deficiency in Type 1 diabetic patients which suggests a contributory role in pathogenesis to Type 1 diabetes. Even with this data there is no dose of vitamin D that is recommended to decrease the incidence of Type 1 diabetes.

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3610375/

Chakhtoura, Marlene, and Sami T. Azar. "The Role of Vitamin D Deficiency in the Incidence, Progression, and Complications of Type 1 Diabetes Mellitus." National Center for Biotechnology Information. U.S. National Library of Medicine, 13 Mar. 2013. Web. 20 Apr. 2013.