Tuesday , November 21 2017
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Type 2 Diabetes Linked with Colorectal Cancer

A longer duration of obesity also increased risk of colorectal cancer for diabetic patients…

Dutch researchers have assessed the risk of colorectal cancer associated with type 2 diabetes, as compared with a nondiabetic reference population.

They conducted an observational population-based cohort study within the Clinical Practice Research Datalink (1987–2012). All patients (≥18 years) with at least one prescription for an antidiabetic drug (n = 300,039) were matched (1:1) by birth year, sex, and practice to a comparison cohort without diabetes. Cox proportional-hazards models were used to derive adjusted hazard ratios (HRs) for colorectal cancer associated with type 2 diabetes. Within the diabetic cohort, associations of colorectal cancer with treatment stages and duration of obesity (BMI ≥30) were studied.

After 4.5 years of follow up, a total of 2,759 cases of colorectal cancer were detected among the diabetic study population. The results demonstrated that type 2 diabetes was associated with a 1.3 fold increase in risk of colorectal cancer (HR 1.26 [95% CI 1.18-1.33]). Within the diabetic patients, there was no association found in the treatment stages. The duration of obesity of 4-8 years has demonstrated a statistically significant difference in risk of colorectal cancer (HR 1.19[1.06-1.34]) and >8 years (1.28[1.11-1.49]).

The authors concluded that type 2 diabetes is associated with a moderately increased risk of colorectal cancer. Within the diabetic patients, longer duration of obesity also showed increased risk of colorectal cancer.

Practice Pearls:

  • This study has demonstrated that risk of colorectal cancer increases with longer duration of obese type 2 diabetes patients.
  • More studies are necessary to determine whether the increased risk of colorectal cancer is reversible through weight loss.

Peeters PJ, Bazelier MT, Leufkens HG, et al. The Risk of Colorectal Cancer in Patients With Type 2 Diabetes: Associations With Treatment Stage and Obesity. Diabetes Care.2014; 10.2337-1175