Tuesday , October 24 2017
Home / Conditions / Alzheimer's / Type 2 Diabetes Linked to Higher Dementia Risk

Type 2 Diabetes Linked to Higher Dementia Risk

Results of a new study suggest that there is a general association between high adiposity and an increased risk of dementia, particularly among the “younger” elderly. In addition to age, other patient factors can confound this association. "The few studies exploring the association between adiposity, measured by body mass index (BMI), and dementia in elderly persons were conflicting," Dr. Jose A. Luchsinger and colleagues from Columbia University College of Physicians and Surgeon in New York, write.

The researchers hypothesized that higher adiposity is associated with higher dementia risk, and that this relation is attenuated by age. Their study included 893 subjects with BMI data, 907 with waist circumference data, and 709 with a second weight measurement. At baseline, all subjects were free of dementia.

At 5-year follow-up, evaluations revealed 181 incident dementia cases, 112 Alzheimer’s disease cases, and 53 dementia cases associated with stroke. The mean patient age was 77.0 years.

Patients in the third BMI quartile had a lower dementia risk than those in the first BMI quartile, after adjusting for demographics and apolipoprotein E-epsilon-4 status. Patients in the third BMI quartile also had a lower Alzheimer’s disease risk. Those in the second BMI quartile had a lower risk of dementia associated with stroke.

"In persons younger than 76 years, the association between BMI quartiles and dementia resembled a U shape," Dr. Luchsinger’s team explains. "The second (HR, 0.4) and third (HR, 0.3) quartiles were related to lower risk, while the fourth (HR, 1.0) was similar to the reference," they note. "In older people (at least 76 years), dementia risk decreased with increasing BMI; this association was almost statistically significant (fourth quartile HR, 0.6; p = 0.07 for trend)."

For all of the subjects, an association was observed between those in the fourth BMI quartile of waist circumference and a higher risk of stroke-related dementia. Subjects younger than 76 who were in the fourth quartile of waist circumference had an increased risk of dementia (HR, 2.3; p = 0.03 for trend) and Alzheimer’s disease (HR, 5.1; p = 0.04 for trend).

Weight loss was associated with a higher risk of dementia and dementia associated with stroke. Weight gain was related to a higher risk of dementia associated with stroke only.

Arch Neurol 2007;64:392-398.

=====================================

Advertisement:
Breaking News from the American Diabetes Association 66th Scientific Sessions
Did you miss the ADA Scientific Sessions in Washington, DC?  Get up to speed on the latest research and updates to current knowledge on diabetes and dyslipidemia-FREE CME Activities from the ADA Scientific Sessions are now available!  Click here to access the interactive CME newsletter summary of several presentations relevant to clinical practice and the CME case-based slide and audio presentations on the real-world management of patients with diabetes and dyslipidemia recorded at the ADA meeting.  Don’t miss this opportunity to learn the latest clinical updates from one of the year’s most critical diabetes events! http://www.cemedicus.com/diabetes