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Type 2 Diabetes Antibody Increases Glucose Infusion Rate by 291 Percent

Apr 27, 2011

DiaMedica announces positive and important activity with DM-204, its lead monoclonal antibody….

In a gold-standard animal model for testing Type 2 diabetes therapies, administration of DM-204 caused a significant increase in glucose utilization. This study in combination with the antibody’s recently reported lowering of high blood pressure — the most common complication experienced by diabetes patients — highlight DM-204’s potential to become a breakthrough treatment for Type 2 diabetes.

In a preclinical study, DM-204’s activity was measured using a hyperinsulinemic euglycemic clamp model. Rats acutely treated with a single dose of DM-204 demonstrated a 291% increase in maximal glucose infusion rate (p<0.0035). This significant increase in glucose disposal was associated with a 160% overall average increase (p<0.0066) in the glucose infusion rate in order to maintain euglycemia.  DM-204 also showed positive results in two other Type 2 diabetes models.  “DM-204 had a clear effect on whole body glucose utilization,” stated Dr. Alan Cherrington, Professor of Medicine at Vanderbilt University, past President of American Diabetes Association, member of DiaMedica’s scientific advisory board, “I am very keen to see testing of this antibody move forward.”
DM-204 was previously reported to reduce blood pressure in an earlier study. High blood pressure (hypertension) is the primary risk associated with Type 2 diabetes, with 70% of Type 2 diabetics at increased risk of stroke and cardiovascular disease as a result of having high blood pressure.  The antibody lowered systolic blood pressure by 15 mmHg (p<0.05).  “These exceptional results of DM-204 for Type 2 diabetes and our earlier hypertension results offer a promising and highly differentiated product,” said Mr. Rick Pauls, CEO of DiaMedica. “A monoclonal antibody with potent dual capabilities to normalize blood glucose and blood pressure could replace currently used combination therapies of diabetic and anti-hypertensive drugs. These could be administered as infrequently as once a month.  DM-204 has the potential to fundamentally change the treatment regimen for diabetic patients.”

DiaMedica, news release