You are correct...
Which of the following changes in tissue is common to
all of the
microvascular complications of diabetes?
1. Thickening of base membrane
2. Endothelial cell changes
3. Pericyte cell death
4. All of the above
There is a common pathologic change no matter whether you look at the
retina, the kidney, or the nerve. The changes that one sees are related
to base membrane, endothelium, and pericytes. This shows the retina,
the glomerulus, and the nerve. The changes are those of thickening of
base membrane, endothelial cell changes, and pericyte cell death. These
are common to all the so-called microvascular complications of diabetes.
And we know that the progression of this abnormality relates to the
severity of the complication. The more severe the base membrane thickening,
whether it's in the kidney or the nerve, the more severe the nerve and
renal damage.
The Common Pathophysiology of Diabetic Microvascular Complications
by Rayaz A. Malik, MB ChB, MRCP, PhD
The Link Between Diabetes and Its Complication
The Molecular Basis for Vascular Changes
The Functional/Physiologic Basis for Vascular Changes
Microangiopathy Is Present in Early-Stage Disease
Pericyte Apoptosis in Diabetes
Diabetic Nephropathy
Treatment of Microvascular Complications
Print This Page
