You are correct...
The Insulin Lantus is a long-acting insulin
that works differently from other intermediate and long acting insulin’s.
Which is false regarding
the mechanism of action of Lantus (glargine)
1. The molecular structure of Lantus
differs from human insulin by two modifications to the human insulin
structure: One modification is a replacement of the amino acid asparagine
with glycine at position A23
2. There are two additional arginines added to the
c-Terminus of the B-chain.
3. At pH 4, Lantus is completely soluble.
4. After injection into the subcutaneous tissue, the
acidic solution is neutralized, leading to formation of microprecipitates
from which small amounts of Lantus are slowly released over 24 hours.
The molecular structure of Lantus differs
from human insulin by two modifications to the human insulin structure:
a replacement of the amino acid asparagine with glycine at position
A21; and the addition of two arginines added to the C-terminus of the
B-chain. Lantus is designed to have low aqueous solubility at neutral
pH. At pH 4, Lantus is completely soluble and after injection into the
subcutaneous tissue, the acidic solution is neutralized, leading to
formation of microprecipitates from which small amounts of Lantus are
slowly released, resulting in a relatively constant concentration/time
profile over 24 hours with no pronounced peak. This profile allows once-daily
dosing of the basal insulin component of antidiabetic therapy. Lantus
Package Insert.
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