Diabetes
In Control.com Issue #197 |
The Insulin Lantus is a long-acting insulin
that works differently from other intermediate and long acting insulin’s.
Which is false regarding
the mechanism of action of Lantus (glargine)
1. The molecular structure
of Lantus differs from human insulin by two modifications to the human
insulin structure: One modification is a replacement of the amino acid
asparagine with glycine at position A23
2. There are two additional
arginines added to the c-Terminus of the B-chain.
3. At pH 4, Lantus
is completely soluble.
4. After injection
into the subcutaneous tissue, the acidic solution is neutralized, leading
to formation of microprecipitates from which small amounts of Lantus
are slowly released over 24 hours.
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