An acute bout of exercise can place enormous metabolic demands on the human organism.  To maintain homeostasis during exercise, a person must meet increased requirements for oxygen and metabolic substrates through the precise functioning of several regulatory systems.  These include:

• Cardiopulmonary responses that ensure delivery of oxygen and substrates to the working tissues.

• Removal of metabolic by-products.

• The regulation of insulin and counterregulatory hormone secretions.

• The regulation of metabolism in the liver, muscle and adipose tissue..

• All of the above

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