SPECIAL GLP-1 Test Your Knowledge #643: Which of the following are true regarding these two classes of medications?
Lilly is a 45-year-old female, 5'3", 175 lbs, who was diagnosed with type 2 diabetes two years ago.
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She is currently taking Metformin 1000 mg twice daily and Glimepiride 4 mg daily. She has made several lifestyle changes after the diagnosis but still has trouble reaching her goal weight and her glycosylated hemoglobin (HbA1c) only minimally decreased to 7.5%. Her doctor decides to add a third agent to her regimen. The doctor is thinking about adding either GLP-1 agonist or a DPP-IV inhibitor to her regimen.
Which of the following are true regarding these two classes of medications?
(I) GLP-1 agonists have less GI adverse effects compared to DPP-IV inhibitors (II) DPP-IV inhibitors are associated with more weight loss compared to GLP-1 agonists (III) GLP-1 agonists provide better cardioprotection compared to DPP-IV inhibitors
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