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Time-Updated HbA1c Increases Risk of Heart Attack

Researchers found risk for myocardial infarction per 1% in higher HbA1c levels….

Marita Olsson and colleagues, from R&D AstraZeneca in Sweden, examined the risk for myocardial infarction by impaired glycemic control in type 2 diabetes patients diagnosed between 1995 and 2001. The data was drawn from the Clinical Research Data in the United Kingdom.

Based on the study, participants were divided into an early and recent cohort where the correlation between three HbA1c and myocardial infarction was examined. The researchers saw that the risk of MI increased per 1% in higher HbA1c for updated latest and mean HbA1c (1.11 and 1.15, respectively, vs. 1.05), in the overall cohort. The risk estimates were greater in the early cohort compared to the recent cohort.

However, the recent cohort study showed an increased risk of HbA1c less than 6% relative category 6% to 7% (HRs=1.23 [95% CI, 1.08-1.40] and 1.01 [95% CI, 0.84-1.22]). The researchers concluded, “The two time-updated HbA1c variables show stronger associations with risk of MI than baseline HbA1c, and the association between HbA1c and risk of MI has decreased over time.”

Practice Pearls:

  • Time-updated HbA1c correlates with heart attack risk compared to baseline HbA1c.
  • From the study, researchers found the risk for myocardial infarction per 1% in higher HbA1c levels.
  • Monitor HbA1c levels to prevent cardiovascular events.

Olsson, Marita. “Heart Attack Risk Linked to Time-Updated HbA1c Variables.” Diabetes Care. 2015;doi:10.2337/dc14-2351, 10 June 2015.