Limiting food intake to 9-12 hours per day in mice was effective against high-fat, high-fructose and high-sucrose diets…
Researchers from the Salk Institute for Biological Studies in La Jolla, California examined time-restricted feeding (TRF) which confines food access to 9–12 hr during the active phase using both lean and obese mice.
They tested TRF in mice under diverse nutritional challenges showing that TRF attenuated metabolic diseases arising from a variety of obesogenic diets, and that benefits were proportional to the fasting duration. Furthermore, protective effects were maintained even when TRF was temporarily interrupted by ad libitum access to food during weekends, a regimen particularly relevant to human lifestyle. Finally, TRF stabilized and reversed the progression of metabolic diseases in mice with preexisting obesity and type 2 diabetes.
The researchers concluded that they had established clinically relevant parameters of TRF for preventing and treating obesity and metabolic disorders, including type 2 diabetes, hepatic steatosis, and hypercholesterolemia.
Panda, Satchidananda. Time-Restricted Feeding Is a Preventative and Therapeutic Intervention against Diverse Nutritional Challenges, Cell Metabolism, 2 December 2014